Home / Unauthorized

As a science-based company for over 20 years, we value safety, accuracy and transparency, and that ingredients matter -- especially when it comes to ingredients you put into your body. That is why it’s important to clarify misleading marketing materials from Elysium Health’s so-called “NR-E” ingredient. While the marketing language references “NR-E”, that is not what was used in the 2017 study cited by Elysium.  In fact, the study actually used Niagen® which was in Basis™ at the time (but is no longer). “NR-E” is a newly listed ingredient on the Basis™ label as of 2020, and there is no published, peer-reviewed human data on “NR-E” nor has it been reviewed by any regulatory bodies. 

In contrast, Niagen®, the sole active ingredient in Tru Niagen® from ChromaDex, was successfully notified to the U.S. FDA as Generally Recognized as Safe (GRAS) and as a New Dietary Ingredient (NDI). In addition, Tru Niagen® has been approved for sale by Health Canada, the European Commission and Therapeutic Goods Administration (TGA) of Australia—four of the most stringent regulatory bodies in the world. Lastly, Niagen® is shown to safely and effectively increase NAD+ levels in 9 published human studies, which you can find listed on ClinicalTrials.gov.

9 STUDIES SHOWING NIAGEN® SAFELY AND EFFECTIVELY INCREASES NAD+ LEVELS IN HUMANS

1. Trammell et al., 2016 - https://www.nature.com/articles/ncomms12948

  • Single doses of Niagen NR (100mg, 300mg, 1000mg) significantly increased the blood NAD+ metabolome in a dose-dependent manner, with all three doses significantly increasing whole blood NAD+ levels after 24 hours.

  • 12 healthy, non-pregnant subjects (six male and six female) between the ages of 30 and 55 with body mass indices of 18.5–29.9 kg/m2

2. Airhart et al., 2017 - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186459

  • Niagen NR significantly increased whole blood NAD+ levels.

  • 8 healthy male and female volunteers (6 female, 2 male, age range 21–50 years)

3. Martens et al., 2018 - https://www.nature.com/articles/s41467-018-03421-7

  • Niagen NR significantly increased blood NAD+ levels.

  • 24 middle-aged and older healthy male and female volunteers. Consisted of middle-aged and older men and postmenopausal women aged 55−79

4. Dollerup et al., 2018 - https://academic.oup.com/ajcn/article-abstract/108/2/343/5051210?redirectedFrom=fulltext

  • Niagen NR significantly increased NAD+ metabolites in urine.

  • 40 healthy sedentary men with a BMI over 30kg/m2 (obese), aged 40-70 years.

5. Elhassan et al., 2019 -  https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30940-4?_returnURL=https%3A%2F%2Flinkinghub.elsev-ier.com%2Fretrieve%2Fpii%2FS221112471930940-4%3Fshowall%6. 3Dtrue

  • Niagen NR significantly increased levels of NAD+ metabolites, indicating an increase in NAD+ flux.

  • 12 aged (median age of 75 years) and marginally overweight (median BMI of 26.6 kg/m2; range 21–30), but otherwise healthy men

6. Conze et al., 2019 - https://www.nature.com/articles/s41598-019-46120-z

  • Niagen NR (100mg, 300mg, 1000mg) demonstrated a significant, dose-dependent increase in whole blood NAD+ levels.

  • 140 overweight, but otherwise healthy male and female participants

7. Remie et al., 2020 - https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa072/5823793

  • Niagen NR significantly increased markers of NAD+ flux (NAAD and MeNam), which suggests NR increased skeletal muscle NAD+ metabolism.

  • 13 healthy, overweight or obese, sedentary men and women, with a BMI between 27-35 kg/m2, aged 45-65 years old

8. Zhang et al., 2020 - https://www.embopress.org/doi/full/10.15252/ms-b.209495

  • This study was a combination study. Niagen NR, in combination with metabolic cofactors L-serine, N-acetyl-L-cysteine, and L-carnitine, increased flux turnovers for NAD+.

  • 9 healthy male subjects, without any medication (aged 26-36 years, BMI 19.4-34.5 kg/m2)

9. Zhou et al., 2020 - https://www.jci.org/articles/view/138538

  • Niagen NR significantly increased whole blood NAD+ levels.

  • 5 Stage D Heart Failure patients. 4 out of 5 subjects completed the study

NIAGEN® is the only nicotinamide riboside that has been successfully notified to the US FDA as generally recognized as safe (GRAS) and successfully reviewed twice under the FDA’s new dietary ingredient (NDI) notification program.

LOOK FOR “NIAGEN®” ON THE LABEL

NR is a patented ingredient, only sold as NIAGEN®. ChromaDex holds the patent rights to NR, and sells the ingredient to consumers as TRU NIAGEN®. 

If you are taking or plan to purchase an NR supplement, look at your label to ensure “NIAGEN®” appears under the “Supplement Facts.” Any nicotinamide riboside product that does not say “NIAGEN®” on its label does not contain nicotinamide riboside that has been successfully notified to the FDA.

PURCHASE FROM THESE AUTHORIZED DISTRIBUTORS

TRU NIAGEN® – Directly from ChromaDex

NAD+ Cell Regenerator™ – Life Extension


Previously, ChromaDex sold its NIAGEN® ingredient which was featured in the following products: 

Ceragen

Doctor’s Best Energy featuring Niagen

MitoBoost

NiaSun

NR 200 + Lions Mane (Thrive Now)

BioCoenzymated Nicotinamide Riboside (Natural Factors)

N(R) Capsule NAD+ Booster™ – HPN

AVOID UNAUTHORIZED DISTRIBUTORS & BRANDS

ChromaDex is unable to identify all persons and companies who falsely claim to be authorized nicotinamide riboside distributors. We cannot guarantee the authenticity of other products sold via online shopping sites. 

If you have questions, please feel free to contact us at customercare@truniagen.com.